6/4/2023 0 Comments Antiplatelet medication![]() ![]() History of thrombocytopenia. Anagrelide decreased bone marrow production of platelets.Closed head injuries. Increased risk of bleeding in injured blood vessels of the brain.Recent surgery. Increased risk of bleeding in unhealed blood vessels.Known bleeding disorder. Increased risk of excessive blood loss.Prevent severe hypersensitivity reactions. Therapy is always started at the lowest level possible and adjusted accordingly.Careful monitoring of liver and kidney function is important for this age group.Are more susceptible to drug toxicity and drug-to-drug interactions.On the other hand, for lactating women, it is generally inadvisable. For pregnant women, it is not advisable unless the benefit to the mother would clearly outweigh the risk for the fetus.It should also be emphasized that periodic blood tests is expected to monitor the effect of therapy. Other drugs taken should be documented because there are a lot of drug interactions with these drug class.applying firm pressure) as well as what signs of bleeding should be watched out for. It is also important that adults are educated on what to do should bleeding occurs (e.g.using electric razor and soft-bristled toothbrush). Caution is particularly important to prevent injury (e.g.Only heparin and warfarin are indicated for children but these drugs alone require careful dose calculation.One drug, anagrelide, blocks the production of platelets in the bone marrow.Other indications include maintenance of arterial and venous grafts, preventing cerebrovascular occlusion, and including them as adjunct to thrombolytic therapy for treatment of myocardial infarction.Primarily indicated for cardiovascular diseases that have potential for development of vessel occlusion.Also, platelet-platelet interaction as well as interaction of platelets to clotting chemicals are prevented. ![]() ![]() By blocking receptor sites on the platelet membrane, platelet adhesion and aggregation is inhibited.Through this, formation of platelet plug is decreased. This drug class exerts its action by decreasing the responsiveness of platelets to stimuli that cause it to clump or aggregate.Bone marrow disorders: characterized by insufficient quantity of platelets rendering them ineffective.Liver disease: characterized by non-production of proteins and clotting factors necessary for clot formation.Hemophilia: characterized by genetic lack of clotting factors. ![]() These are treated by drugs that promote the clotting process. On the other hand, less common hemorrhagic disorders is characterized by excessive bleeding. These disorders are treated by drugs that interfere with normal coagulation process to prevent formation of clots. Manifestations include hypoxia, anoxia, and even necrosis. CAD) which involve overproduction of clots which result into decreased blood flow and total vessel occlusion. Thromboembolic disorders include medical conditions (e.g. Disease Spotlight: Thromboembolic and Hemorrhagic Disordersĭisorders that directly affect coagulation process are divided into two main categories: 1) thromboembolic disorders, which involve overproduction of clots and 2) hemorrhagic disorders, which is characterized by ineffective clotting process leading to excessive bleeding. ![]()
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